Restylane is designed to smooth wrinkles and shape facial contours. It is a clear gel made of hyaluronic acid, a natural substance that is found throughout your body, so it carries no risk of allergic reaction. It works best on fine lines and medium wrinkles. The most common areas for treatment are glabellar lines (area between the eyebrows) and the nasolabial folds (root of the nose to the angle of your mouth). Restylane binds with water so it is able to remain in your skin for up to six months.